1eb1

About this Structure
1EB1 is a 3 chains structure of sequences from Homo sapiens. 1EB1 is an all beta protein, and classified under the Trypsin-like serine proteases fold. Full crystallographic information is available from OCA.

Protein Function
Prothrombin cleavage results in the creation of thrombin, a coagulative agent in plasma and is connected to fibrinolysis and platelet activation. During this process several peptides involved in the conversion are released into the plasma, and the remaining protein splits into two portions.(http://www.uniprot.org/citations/3759958)

It has been shown that prothrombin has a statistically significant connection to the occurrence of ischemic stroke with the presence of the G20210A mutation, though the cause was not isolated to prothrombin alone (http://www.uniprot.org/citations/15534175).

Reference
Page seeded by OCA on Tue Feb 17 12:21:06 2009